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  • Title: [Veno-occlusive disease after liver transplantation. Association of acute cellular rejection and toxicity of azathioprine].
    Author: Mion F, Cloix P, Boillot O, Gille D, Bouvier R, Paliard P, Berger F.
    Journal: Gastroenterol Clin Biol; 1993; 17(11):863-7. PubMed ID: 8143956.
    Abstract:
    Azathioprine vascular hepatotoxicity has been described mainly after renal transplantation. We report a new case in a patient who developed veno-occlusive disease of the liver 3 weeks after liver transplantation; regression of lesions were observed after discontinuation of azathioprine therapy. In this case, azathioprine hepatotoxicity may have been enhanced by a previous episode of severe, acute rejection prevailing in the hepatic veins. After liver transplantation, the diagnosis of azathioprine hepatotoxicity is difficult but should be suspected in the presence of non-inflammatory small hepatic veins lesions. Early withdrawal of the drug is mandatory for complete recovery.
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