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  • Title: [The possible effect of membrane-pathological processes on the atherogenicity of hypertension].
    Author: Gapon LI, Shafer MZh, Kokarev AN, Velizhanina IA.
    Journal: Kardiologiia; 1993; 33(9):44-6, 5. PubMed ID: 8145442.
    Abstract:
    A total of 110 young males suffering from hypertensive disease (HD) were studied. Out of them 21 patients had concurrent HD. As HD progresses, there is an accumulation of free cholesterol in the lipid bilayer of erythrocytic membranes, which promotes the limitation of higher membrane permeability for calcium ions. The excessive accumulation of cholesterol also results in an additional decrease in Na+K+. ATPase activity and Ca(2+)-ATPase inhibition in the erythrocytic membranes in hypertensives, which produced atherogenic effects.
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