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  • Title: [Study of anti-HIV activity of azidothymidine and fluorothymidine 5'-phosphonates].
    Author: Mamaeva OA, Pliasunova OA, Pokrovskiĭ AG, Diatkina NB, Arzumanova AA.
    Journal: Mol Biol (Mosk); 1994; 28(1):137-42. PubMed ID: 8145741.
    Abstract:
    It was established that 5'-phosphonates of 3'-azido-2',3'-dideoxythymidine (AZT) inhibit HIV reproduction in the MT-4 cell line as well as AZT. However, the viability of HIV-infected MT-4 cells after treatment with phosphonates was considerable higher that after AZT treatment. Inhibitory activities of 5'-phosphonates of 3'-fluoro-2',3'-dideoxythymidine (FLT) on HIV-infected MT-4 cells were rather low. The mechanism of action of these derivatives and prospects for their application for suppressing HIV infection are discussed.
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