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  • Title: [Immunologic responses of the body to tumors induced by DMBA].
    Author: Lomakin MS, Maĭskiĭ IN, Larin AS, Levitina VL.
    Journal: Vopr Onkol; 1975; 21(7):66-72. PubMed ID: 814713.
    Abstract:
    As a result of the complex immunobiological study in an autologous system on the models of DMBA induced tumors in muscular tissue there were shown 3 types of cell response to primary tumors, their metastases and autotransplantation: no response, moderate and very pronounced reaction. In a definite percentage of cases autologous peritoneal macrophages were found to inhibit malignant cells in autotransplantation. The percentage of positive inoculations and an average weight of transplants of primary tumors and their metastases at the moment of highest transplantation immunity (12-14 days) have been definitely correlated with the intensity of cell response developed in these tissue, and also are dependent on individual features of proper malignant cells.
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