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  • Title: Etiology and pathophysiology of preeclampsia.
    Author: Dekker GA.
    Journal: Zentralbl Gynakol; 1994; 116(2):57-60. PubMed ID: 8147189.
    Abstract:
    The possible involvement of genetic and immune mechanisms in the etiology of preeclampsia has attracted increasing attention. Preeclampsia is characterized by a generalized disturbance in endothelial physiology, and not merely by an isolated defect in vascular prostacyclin synthesis. The increased production of oxygen free radicals and/or elastase by activated lymphoid cells in the pregnant decidua, a mainly lymphoid tissue, may be the link between the hypothetical immunologic mechanisms and the endothelial injury occurring in preeclampsia.
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