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  • Title: Photophysical alterations of erythrocyte membrane by 4,5',8-trimethyl psoralen: membrane response towards psoralen phototherapy.
    Author: Nivsarkar M, Kumar GP, Laloraya M.
    Journal: Biochem Biophys Res Commun; 1994 Mar 30; 199(3):1413-21. PubMed ID: 8147885.
    Abstract:
    Despite the wide and versatile use of psoralen phototherapy in various dermal diseases including psoriasis and leukoderma, the proposed mechanism of action of psoralen is disputed. This study launches an original documentation of free-radical resulting in erythrocyte membrane damage studied by spin-labeling using the probes malnet and 5 doxyl stearate as protein and lipid domains, respectively. Both Type I and Type II photodynamics appear plausible and the therapeutic aspects of this innovation are being verified.
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