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  • Title: Synthesis of 7-substituted-4-(3',4',5'-trisubstituted-1-pyrazolyl)pyramido-[5,4-c] cinnolines and their anti-inflammatory activities.
    Author: Nargund LV, Jose R, Reddy YS.
    Journal: Arzneimittelforschung; 1994 Feb; 44(2):156-8. PubMed ID: 8147949.
    Abstract:
    Eight title compounds were synthesised from substituted anelines. All compounds were tested for inhibition of bovine serum albumin denaturation. Few selected compounds were studied for their ability to provide protection against carrageenin-induced edema in rat paw and to inhibit denaturation of bovine serum albumin in an attempt to elucidate their cellular mechanism of action. There was no relationship between anti-inflammatory activity of 7-substituted-4-(3',4',5'-trisubstituted-1-pyrazolyl)pyrimido[5,4- c] cinnolines and their bovine serum albumin denaturation effectiveness.
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