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  • Title: Electron-beam therapy in scleredema adultorum with associated monoclonal hypergammaglobulinaemia.
    Author: Angeli-Besson C, Koeppel MC, Jacquet P, Andrac L, Sayag J.
    Journal: Br J Dermatol; 1994 Mar; 130(3):394-7. PubMed ID: 8148285.
    Abstract:
    We report a case of scleredema adultorum (Buschke's disease) associated with an IgA kappa monoclonal hypergammaglobulinaemia. A significant improvement in the skin was obtained with electron-beam therapy. Scleredema would appear to be linked to monoclonal hypergammaglobulinaemia, but the relationship between the skin disorder and the immunoglobulin abnormality remains to be elucidated.
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