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  • Title: Migraine: possible role of platelet insensitivity to prostaglandin E1 (PGE1).
    Author: Cerneca F, de Luyk S, Radillo O, Simeone R, Mangiarotti M.
    Journal: Funct Neurol; 1993; 8(6):403-8. PubMed ID: 8150318.
    Abstract:
    Platelet aggregation inhibition, induced by prostaglandin E1 (PGE1), was evaluated in 38 patients affected by migraine. Our data indicate a complete insensitivity to PGE1 in these subjects. The insensitivity to PGE1 leads to decreased cyclic-AMP (cAMP) levels, determining an imbalance in the inhibitory mechanism. From this observation we can suppose that the decreased affinity of PGE1-receptors, causing decreased cAMP levels, may be involved in pathogenesis of migraine.
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