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  • Title: [An observation of the anticarcinogenic effect of mitoxantrone-polybutylcyanoacrylate-nanosperes].
    Author: Zhang Z, Liao G, Hou S, Bai S, Zhang X.
    Journal: Hua Xi Yi Ke Da Xue Xue Bao; 1993 Dec; 24(4):381-4. PubMed ID: 8150436.
    Abstract:
    This paper reports the result of an experiment on the anticarcinogenic effect of liver targeted drug delivery system-mitoxantrone-polybutylcyanoacrylate-nanospheres (DHAQ-PBCA-NS) by using a model of heterotopic and orthotopic transplantation of human hepatocellular carcinoma (HCC) in nude mice. No significant difference was noted between the anti-HCC effects of mitoxantrone and dexerubicin, but the anti-orthotopic transplanting HCC effect of mitoxantrone-nanospheres was obviously higher than that of mitoxantrone and dexerubicin by comparison of tumor inhibition rates and proliferating cell nuclear antigen (PCNA). The result showed the applicability of mitoxantrone-nanospheres.
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