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  • Title: Effects of time discrepancies between input and myocardial time-activity curves on estimates of regional myocardial perfusion with PET.
    Author: Herrero P, Hartman JJ, Senneff MJ, Bergmann SR.
    Journal: J Nucl Med; 1994 Apr; 35(4):558-66. PubMed ID: 8151375.
    Abstract:
    UNLABELLED: Estimates of myocardial perfusion with PET using kinetic models require faithful recording of radioactivity content in blood and myocardium. Typically the arterial time-activity curve is obtained by placing a region of interest (ROIs) within the left atrial or left ventricular cavity. However, curves generated from these regions appear earlier in time than tissue time-activity curves obtained from ROIs within the myocardial tissue, and such time discrepancies can lead to errors in flow estimates. METHODS: The magnitude of these time discrepancies and their effect on estimates of regional myocardial perfusion using oxygen-15-water were measured in 30 normal subjects evaluated at rest and again after administration of dipyridamole. RESULTS: Under baseline conditions, the left atrial curve appeared 0.97 +/- 0.67 (s.d.) before the ascending aorta input curve (p < 0.05) and estimated perfusion decreased from 1.28 +/- 0.28 ml/g/min using the left atrial curve uncorrected for time to 0.98 +/- 0.27 ml/g/min after correction (p < 0.05). After dipyridamole, the left atrial curve appeared 0.68 +/- 0.72 sec before the ascending aorta curve (p < 0.05) and estimated perfusion decreased from 3.60 +/- 1.40 ml/g/min using the left atrial curve uncorrected for time to 3.24 +/- 1.26 ml/g/min using the time-corrected curve (p < 0.05). Because the magnitude of time discrepancies between the left ventricular and ascending aortic curves was less (0.25 +/- 0.34 and 0.19 +/- 0.23 sec at rest and after dipyridamole, respectively), effects on flow estimates were more modest. CONCLUSIONS: The results of this study demonstrate that time discrepancies between input and tissue time-activity curves can affect estimates of myocardial flow. Correction for this potential source of error is proposed.
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