These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Adrenergic excitation of cutaneous nociceptors in chronically inflamed rats.
    Author: Sato J, Suzuki S, Iseki T, Kumazawa T.
    Journal: Neurosci Lett; 1993 Dec 24; 164(1-2):225-8. PubMed ID: 8152606.
    Abstract:
    To probe the mechanisms underlying sympathetically maintained pain, the effects of lumbar sympathetic chain stimulation (SS) and close arterial injection of norepinephrine (NE) on cutaneous nociceptor activities were studied in adjuvant inflamed rats. Two to 28 weeks after adjuvant treatment, single nerve recordings of polymodal receptors from the saphenous nerve were performed. In treated rats but not in controls, SS and NE were excitatory in 35-40% of units. Yohimbine and CH-38083 blocked NE excitation, but prazosin did not. Our data show that chronic inflammation initiates circumstances in which alpha 2-adrenoceptor-mediated sympathetic activity excites some nociceptors.
    [Abstract] [Full Text] [Related] [New Search]