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  • Title: HLA-DP does not contribute towards susceptibility to systemic lupus erythematosus.
    Author: Davies EJ, Hutchings CJ, Hillarby MC, Donn RP, Cooper RG, Hay EM, Bernstein RM, Holt PJ, Grennan DM, Ollier WE.
    Journal: Ann Rheum Dis; 1994 Mar; 53(3):188-90. PubMed ID: 8154937.
    Abstract:
    OBJECTIVES: To determine whether HLA-DP genes are involved in determining susceptibility to systemic lupus erythematosus (SLE). METHODS: HLA-DPA1 and DPB1 genes were amplified by PCR of DNA samples from a panel of patients with SLE and normal controls. Amplified DNA was blotted on to nylon filters and probed with sequence-specific oligonucleotide (SSO) probes. RESULTS: No DPA1 or DPB1 allele was significantly associated with SLE, or with any immunological or clinical subset of SLE. Evidence was found for only limited linkage disequilibrium between HLA-DP and HLA-DQ/DR variants, and none between HLA-DP and the TAP2 gene. CONCLUSIONS: These data indicate that HLA-DP genes do not contribute towards determining susceptibility to SLE.
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