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  • Title: Effects of eosinophilotropic cytokines on differentiation of an eosinophil cell line, YY-1.
    Author: Ueno M, Watanabe K, Tsurufuji S, Hirashima M.
    Journal: Int Arch Allergy Immunol; 1994; 104 Suppl 1(1):60-2. PubMed ID: 8156008.
    Abstract:
    Differentiation of an eosinophilic cell line, YY-1, was induced by treatment with 0.3 mM butyric acid (BA). The effects of eosinophilotropic cytokines, such as IL-3, IL-5, and GM-CSF on BA-induced differentiation, especially in the chemotactic response to ECF, was examined. Five STO-2-derived ECFs, IL-5, C5a, and fMLP were used as eosinophil chemoattractants. The effects of the cytokines on the chemotactic response of YY-1 greatly differed according to the ECF used. It was thus suggested that heterogeneity in the chemotactic response of eosinophils depends on the cytokines which act on eosinophils during differentiation.
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