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  • Title: Administration of amyloid beta-peptides into the medial septum of rats decreases acetylcholine release from hippocampus in vivo.
    Author: Abe E, Casamenti F, Giovannelli L, Scali C, Pepeu G.
    Journal: Brain Res; 1994 Feb 04; 636(1):162-4. PubMed ID: 8156403.
    Abstract:
    The septum of male Wistar rats was injected with synthetic beta-amyloid fragments, beta 12-28, beta 25-35 and beta 1-40, and hippocampal acetylcholine (ACh) release was evaluated by transversal microdialysis. A marked decrease in basal and K(+)-evoked ACh release was found 7 or 21 days after injection of 5 nmol of beta 12-28 and beta 25-35, or 3 nmol of beta 1-40, respectively. These data indicate that septal injection of beta-amyloid peptides causes hypofunction of the septo-hippocampal cholinergic system.
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