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  • Title: Histamine does not play an essential role in electrocortical activation during waking behavior.
    Author: Servos P, Barke KE, Hough LB, Vanderwolf CH.
    Journal: Brain Res; 1994 Feb 04; 636(1):98-102. PubMed ID: 8156416.
    Abstract:
    Intraperitoneal injection of alpha-fluoromethylhistidine (alpha-FMH; 200 mg/kg), a specific inhibitor of histidine decarboxylase produced a severe depletion of neocortical and hippocampal histamine 3 h later as determined by a radioenzymatic assay. This treatment had no obvious effect on either low voltage fast activity (LVFA) in the neocortex or on rhythmical slow activity (RSA) in the hippocampus during an 8 h recording period during the rats' light cycle. Scopolamine-sensitive LVFA, scopolamine-resistant LVFA and scopolamine-resistant hippocampal RSA all appeared unaffected. This suggests that any contribution histamine makes to electrocortical activation is probably indirect, acting via other transmitter systems.
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