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  • Title: Effects of endotoxin, interleukin-1 beta and prostaglandin injections on fever response in broilers.
    Author: Macari M, Furlan RL, Gregorut FP, Secato ER, Guerreiro JR.
    Journal: Br Poult Sci; 1993 Dec; 34(5):1035-42. PubMed ID: 8156420.
    Abstract:
    1. The effect of endotoxin, interleukin-1 beta and prostaglandin on fever response was studied in 80 broilers (Hubbard strain). Endotoxin (E. coli, LPS) was injected i.v. (1.5 micrograms/kg) and icv (1.5 micrograms/bird); interleukin-1 (human recombinant IL-1 beta, 80 pg/bird) and prostaglandin E2 (5 micrograms/bird) were injected icv. Indomethacin (10 mg/kg, i.v.) pretreatment was also used before i.v. endotoxin injection. 2. The results showed that indomethacin was able to block the fever response induced by i.v. endotoxin injection, and IL-1 beta and PGE2 were both effective in producing fever when injected icv. These data suggest a prostaglandin-mediated fever response by broilers, and also a strong evidence of the involvement of endogenous pyrogen (interleukin-1) in fever response in birds.
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