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  • Title: [Clinical significance of changes in plasma renin-angiotensin aldosterone system in patients with high altitude pulmonary edema].
    Author: Li YY, Luo DC, Xiao Q.
    Journal: Zhonghua Nei Ke Za Zhi; 1993 Mar; 32(4):232-4. PubMed ID: 8156847.
    Abstract:
    Plasma levels of renin activity, angiotensin II and aldosterone were determined in 16 patients with high altitude pulmonary edema (HAPE) with radioimmunoassay and compared with those in the controls including 9 patients with high altitude acute response (HAAR) and 14 health subjects. All of them arrived recently in Lhasa, a place with an altitude of 3,658 m. The results showed that the concentration of plasma renin activity, angiotensin II, and aldosterone was significantly increased (P < 0.05-0.001) in patients with HAPE and higher than that in the controls. It is suggested that the increase plays a role in the development of pulmonary edema in patients with HAPE.
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