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  • Title: Cholesterol synthesis inhibitors inhibit more than cholesterol synthesis.
    Author: Kasiske BL, O'Donnell MP, Kim Y, Atluru D, Keane WF.
    Journal: Kidney Int Suppl; 1994 Feb; 45():S51-3. PubMed ID: 8158898.
    Abstract:
    The beneficial effects of HMG-CoA reductase inhibition in models of progressive glomerular injury may not all be due to reductions in circulating lipoproteins and decreases in glomerular lipoprotein deposition. Indeed, HMG-CoA reductase inhibitors may have direct effects on glomerular mesangial cells that could explain the amelioration of renal injury. Specifically, HMG-CoA reductase inhibitors block the synthesis of isoprenoids that are necessary for mesangial cell proliferation and other important cell functions. Thus, protein isoprenylation may play a critical role in the pathogenesis and treatment of lipid-induced glomerular injury.
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