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  • Title: [The mechanism of the pathogenesis of drug-induced parkinsonism (experimental biochemical and bioelectrical research on the action of haloperidol)].
    Author: Dovedova EL, Popova NS.
    Journal: Zh Nevrol Psikhiatr Im S S Korsakova; 1993; 93(6):15-8. PubMed ID: 8160492.
    Abstract:
    Haloperidol was administered to rabbits in a dose 500 micrograms/kg during 60 min or 30 days. Its effects were studied in enzymes controlling neurotransmitters utilization--monoamine oxidase (MAO) A and B, acetylcholine esterase (ACE) in synaptosomes subfractions and mitochondria of the cells--and on the content of biogenic amines in the sensomotor cortex and caudate nucleus tissues. It was found that this neuroleptic induces reciprocal changes in MAO specific activity (a decrease in MAO B activity and an increase in MAO A), a fall in the levels of dopamine and noradrenaline in unchanged levels of 5'-HT and 5'-HYAA.
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