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  • Title: Evolution of aurosomes in rabbit synovial membrane.
    Author: Oryschak AF, Ghadially FN.
    Journal: Virchows Arch B Cell Pathol; 1976 Feb 11; 20(1):29-39. PubMed ID: 816069.
    Abstract:
    Intra-articular injection of sodium aurothiomalate (Myochrysine) into rabbit knee joints produced lysomes (aurosomes) of a characteristic morphology in synovial intimal cells and subsynovial macrophages. Such lysosomes are distinct and different from other lysosomes and those seen after injection of sodium thiomalate. A study of the morphological events that occur after injection of gold salt shows that at first the aurosome contains electrondense granules but later membranous formations (myelinoid membranes) presenting as rod-like and curled structures develop. With electron probe x-ray analysis, gold, phosphorus, and traces of calcium were detected in the aurosome.
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