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  • Title: M2-specific muscarinic cholinergic receptor-mediated inhibition of cardiac regulatory protein phosphorylation.
    Author: Gupta RC, Neumann J, Boknik P, Watanabe AM.
    Journal: Am J Physiol; 1994 Mar; 266(3 Pt 2):H1138-44. PubMed ID: 8160816.
    Abstract:
    Acetylcholine acting via muscarinic cholinoceptors decreased phosphorylation of phospholamban and troponin I without reducing adenosine 3',5'-cyclic monophosphate (cAMP) levels or cAMP-dependent protein kinase activity ratio in the presence of 10-100 nM isoproterenol in guinea pig ventricular myocytes. The effect of acetylcholine was more pronounced when adenosine deaminase (5 U/ml) was present and incubation period was short (10 s). Okadaic acid, an inhibitor of protein phosphatase activity, blocked the acetylcholine-mediated inhibition of isoproterenol-stimulated phosphorylation of phospholamban. It is suggested that acetylcholine reduces protein phosphorylation by a cAMP-independent mechanism in guinea pig ventricular myocytes.
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