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Title: Detection of parvovirus B19 in fetal autopsies. Author: Schwarz TF, Nerlich A, Hillemanns P. Journal: Arch Gynecol Obstet; 1993; 253(4):207-13. PubMed ID: 8161255. Abstract: In a 10-year retrospective study we examined the incidence of parvovirus B19 (B19)-related hydrops fetalis in fetal autopsies (n = 1,299) carried out between 1982 and 1991. Intrauterine death had occurred in 399 cases (30.7%); in 42 (10.5%) of these hydrops fetalis was diagnosed. Of these 42 hydropic fetuses, parvovirus B19 infection was identified in 6 (14.3%) cases by the presence of typical erythroblastic nuclear inclusions in hematoxylin-eosin stained tissue and the diagnosis was confirmed by in situ hybridization using a Digoxigenin-labelled B19 DNA probe. The study shows that the overall incidence of B19-associated intrauterine death associated with hydrops fetalis is low. However, B19 infection should be considered in all cases of hydrops fetalis.[Abstract] [Full Text] [Related] [New Search]