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  • Title: Characterisation of sin, a potential recombinase-encoding gene from Staphylococcus aureus.
    Author: Paulsen IT, Gillespie MT, Littlejohn TG, Hanvivatvong O, Rowland SJ, Dyke KG, Skurray RA.
    Journal: Gene; 1994 Apr 08; 141(1):109-14. PubMed ID: 8163161.
    Abstract:
    The staphylococcal beta-lactamase (Bla) transposon Tn4002 has previously been reported to have a high level of insertional specificity for a 1.8-kb region on the plasmid pSK1. Nucleotide sequences of this region and of a related region on plasmid pI9789 were determined. Sequence analysis revealed that these two plasmids contain sin, a gene whose deduced product shows similarity to a family of DNA recombinases. Southern hybridisation analysis indicated that sin is located on alpha-, beta- and gamma-families of Bla plasmids and on pSK1 family plasmids. A region of dyad symmetry located upstream from sin on pSK1 and pI9789 was identified as the site of insertions of Tn552 and Tn4002 in separate isolates.
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