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  • Title: Diazepam binding inhibitor fragment 33-50 (octadecaneuropeptide) immunoreactivity in the cerebellar cortex is restricted to glial cells.
    Author: Vidnyánszky Z, Görcs TJ, Hámori J.
    Journal: Glia; 1994 Feb; 10(2):132-41. PubMed ID: 8168866.
    Abstract:
    The distribution of octadecaneuropeptide (ODN)-like immunoreactivity (LI) and its relationship to gamma-aminobutyric acid (GABA)-LI were investigated in the cerebellar cortex of adult rats with electron microscopy. At the electron microscopic level, ODN-LI was found exclusively in glial cells. In addition to Bergmann glia and its processes, cerebellar astrocytes were also labelled, encapsulating unlabelled neuronal elements of the cerebellum. These ODN-LI glial processes were observed in close apposition to synaptic junctions, but immunoreactivity could not be found in the synaptic cleft or in association with neuronal membranes. Since GABA-LI is always associated with neuronal elements, the colocalization of GABA- and ODN-LI could not be confirmed in the cerebellar cortex. Our results do not support the assumption that ODN is a neuron-specific processing product of diazepam binding inhibitor.
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