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  • Title: Possible interaction of PGF2 alpha with hypothalamus-pituitary-thyroid axis in man.
    Author: Valenti G, Ceda GP, Tarditi E, Banchini A, Vescovi PP, Chiodera P, Coiro V, Butturini U.
    Journal: Prostaglandins; 1976 Feb; 11(2):303-17. PubMed ID: 817369.
    Abstract:
    The possible interactions of PGF2 alpha on the hypothalamus-pituitary-thyroid axis are the object of this study. Firstly a significant direct effect of PGF2 alpha infusion (mg2,5/270 min) on TSH,PRL,LH,FSH and GH pituitary secretion was excluded. Thereafter the possible PGF2 alpha on PRL and TSH pituitary response to TRH was considered: in only two cases PGF2 alpha was able to increase the TSH response. Finally the Authors studied T3 response to endogenous TSH rise induced by TRH: if they consider the mean peak responses of T3 the increase is significant only when PGF2 alpha infusion is performed.
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