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  • Title: [Long-term follow-up results after heavy dose chemotherapy of primary malignant bone tumors of the limbs].
    Author: Cui TH.
    Journal: Zhonghua Zhong Liu Za Zhi; 1993 Jul; 15(4):307-10. PubMed ID: 8174471.
    Abstract:
    Ninety-three cases of primary malignant bone tumors of the limbs were treated for 651 times with preoperative and postoperative HD-MTX-CFR regimen. A number of toxic side reactions appeared, most of which were those of the digestive tract. The side reactions treated symptomatically subsided uneventfully All cases were followed up for 5-7 years, 36 patients died and 57 survived with a 5-year survival rate of 61.3%. A new method to limb salvage was used in 44 cases: the bone segment with tumor was amputated, and replanted back after inactivation with alcohol excision. The five-year survival rate was 63.6%. The excellent results of treatment gave the patients new hope dispelling the misgivings of becoming disabled.
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