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  • Title: Six years of high-level levodopa therapy in severely akinetic parkinsonian patients.
    Author: Barbeau A.
    Journal: Arch Neurol; 1976 May; 33(5):333-8. PubMed ID: 817698.
    Abstract:
    The clinical course and the side effects of high-level levodopa therapy over a six-year period were studied in 80 severely akinetic parkinsonian patients treated for the first time before June 1968. Levodopa improved the quality of life in greater than 53% of patients, but failed to modify the progression of the disease or change the prognosis. Seventeen "idiopathic Parkinson" patients died after a duration of illness of 9.5 years. Despite the drawbacks, levodopa is still the best available treatment for akinetic parkinsonism.
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