These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: An amino-terminal fragment of SV40 T antigen induces cellular DNA synthesis in quiescent rat cells.
    Author: Sompayrac L, Danna KJ.
    Journal: Virology; 1994 May 01; 200(2):849-53. PubMed ID: 8178471.
    Abstract:
    SV40 large T antigen can stimulate cellular DNA synthesis in quiescent cells. Here we report that an SV40 mutant, which expresses only the amino-terminal 147 amino acids of this protein and which does not make small t antigen, stimulates cellular DNA synthesis in quiescent rat cells at levels similar to those achieved with serum stimulation. Thus, the amino-terminal 147 amino acids of large T antigen define a domain of this protein that is sufficient for efficient stimulation of cellular DNA synthesis in the absence of small t antigen.
    [Abstract] [Full Text] [Related] [New Search]