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  • Title: Distinct Streptococcus thermophilus bacteriophages share an extremely conserved DNA fragment.
    Author: Brüssow H, Probst A, Frémont M, Sidoti J.
    Journal: Virology; 1994 May 01; 200(2):854-7. PubMed ID: 8178472.
    Abstract:
    A cross-hybridizing 2.2-kb EcoRI fragment was cloned from two lytic Streptococcus thermophilus bacteriophages with distinct phenotypes. The DNA fragments, which contained two unidentified open reading frames, differed at only 3 of 2207 nucleotide positions. Partial sequencing of a temperate S. thermophilus phage and of a further lytic phage belonging to a different lytic group isolated 20 years earlier from a different geographical area confirmed this extreme sequence conservation. Hybridization of this phage DNA with bacterial host DNA was not observed. The evolutionary implications of these observations are briefly discussed.
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