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  • Title: Identification and characterization of parathyroid hormone/parathyroid hormone-related peptide receptor in cultured astrocytes.
    Author: Hashimoto H, Aino H, Ogawa N, Nagata S, Baba A.
    Journal: Biochem Biophys Res Commun; 1994 Apr 29; 200(2):1042-8. PubMed ID: 8179580.
    Abstract:
    Parathyroid hormone (PTH)/parathyroid hormone-related peptide (PTHrP) receptor expressed in rat cultured cortical type I astrocytes was identified and characterized. Northern blot analysis demonstrated that the PTH/PTHrP receptor mRNA is expressed in astrocytes. A human PTH fragment, PTH [1-34], stimulated adenylate cyclase with the EC50 value of 3 nM, but not phospholipase C. PTH [1-34] changed the morphology of protoplasmic type astrocytes into process-bearing ones. Thus, type I astrocytes possess PTH/PTHrP receptor that is coupled to an adenylate cyclase-activating system but not to phospholipase C.
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