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  • Title: Alternative RNA splicing of calcitonin/calcitonin gene-related peptide minigene transcripts in a thyroid C-cell line.
    Author: Cote GJ.
    Journal: Biochem Biophys Res Commun; 1994 Apr 29; 200(2):993-8. PubMed ID: 8179637.
    Abstract:
    RNA transcripts derived from the calcitonin (CT)/calcitonin gene-related peptide (CGRP) gene are differentially processed in a tissue-specific fashion to produce two unique mRNAs. This RNA processing decision is deregulated in malignant thyroid C-cells. To examine this mechanism of RNA processing, CT/CGRP minigene constructs were transfected into the human medullary thyroid carcinoma TT cell line. RNA derived from the normal CT/CGRP construct paralleled the endogenous pathway to produce both CT and CGRP mRNAs. Mutation analysis and RNA/protein crosslinking were performed in order to clarify trans-acting factor interactions. The data suggest that CGRP production in TT cells results from the coexpression of facilitative and inhibitory factors.
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