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  • Title: Binding of D-galactose-terminated ligands to rabbit asialoglycoprotein receptor.
    Author: Krebs A, Depew WT, Szarek WA, Hay GW, Hronowski LJ.
    Journal: Carbohydr Res; 1994 Feb 17; 254():257-68. PubMed ID: 8180988.
    Abstract:
    The binding affinities of a series of D-galactose-terminated glycerol glycosides and oligosaccharides for the asialoglycoprotein receptor isolated from rabbit liver were determined in vitro using a radioreceptor-inhibition assay with 125I-asialoorosomucoid. The relative affinities of the synthetic ligands increased with the number of exposed D-galactose termini. Of the compounds examined, 1,2,3-tri-O-beta-lactosylglycerol associated with the greatest affinity (estimated Kd = 7.97 x 10(-5) M). Examination of the affinities of the synthetic series indicated that both the number and propinquity of the D-galactose termini influenced the strength of the binding interactions.
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