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Title: Alteration of the voltage-dependence of the twitch tension in frog skeletal muscle fibres by a polyether, Bistramide A. Author: Sauviat MP, Verbist JF. Journal: Gen Physiol Biophys; 1993 Oct; 12(5):465-71. PubMed ID: 8181693. Abstract: Bistramide A, a toxin isolated from Lissoclinum bistratum Sluiter, was applied to frog skeletal muscle fibres. Micromolar concentrations of toxin decreased the amplitude of the twitch tension. Bistramide A shifted the activation and the steady-state inactivation characteristics of the tension on the voltage axis towards more positive and negative membrane potentials respectively. The data suggest that Bistramide A binds to the activated and inactivated state of the dihydropyridine-receptor which senses the T-tubule membrane potential.[Abstract] [Full Text] [Related] [New Search]