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  • Title: Acute renal failure after intravenous immunoglobulin therapy.
    Author: Pasatiempo AM, Kroser JA, Rudnick M, Hoffman BI.
    Journal: J Rheumatol; 1994 Feb; 21(2):347-9. PubMed ID: 8182648.
    Abstract:
    We describe 3 patients given intravenous immunoglobulin (IVIG) who developed acute renal failure temporally related to IVIG therapy. The rise in BUN and creatinine appeared to be transient and reversible 8-14 days after discontinuation of the drug. Renal dysfunction was mild in 2 patients but was severe in one who presented with azotemia, worsening congestive heart failure, severe hyponatremia, hyperkalemia, and metabolic acidosis necessitating hemodialysis. Renal dysfunction was not associated with a specific immunoglobulin preparation or dose.
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