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  • Title: Identification of a binding site in the disintegrin domain of fertilin required for sperm-egg fusion.
    Author: Myles DG, Kimmel LH, Blobel CP, White JM, Primakoff P.
    Journal: Proc Natl Acad Sci U S A; 1994 May 10; 91(10):4195-8. PubMed ID: 8183890.
    Abstract:
    Fertilization and certain later stages in mammalian embryonic development require fusion between membranes of individual cells. The mechanism of eukaryotic cell-cell fusion is unknown, and no surface molecules required for this process have been unequivocally identified. The role of the sperm surface protein fertilin in sperm-egg fusion was tested by using peptide analogues of a potential integrin binding site in the fertilin beta subunit. Peptide analogues that include a TDE sequence from the disintegrin region of fertilin beta are able to bind to the egg plasma membrane and strongly inhibit sperm-egg fusion. These results show that the disintegrin domain of fertilin beta binds to the egg plasma membrane and that this binding is required for membrane fusion.
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