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  • Title: [The protective activity of individual proteins and immunogenic fractions isolated from Rickettsia prowazekii].
    Author: Eremeeva ME, Balaeva NM, Genig VA, Rodionov AV, Belousova LS, Isachkova IP.
    Journal: Zh Mikrobiol Epidemiol Immunobiol; 1994; (1):95-100. PubMed ID: 8184624.
    Abstract:
    The immunogenic properties and protective activity of basic protein I and tris-soluble antigens isolated from R. prowazekii were analyzed in comparison with those of chemical typhus vaccine on the model of anti-infectious immunity in guinea pigs. The analysis revealed that purified protein I has protective activity for guinea pigs, which is less pronounced in protein I from strain E with weak pathogenicity than protein I from strains EVir and Breinl. The activity and immunogenic properties of tris-soluble antigens, especially antigen I, are comparable with those of chemical typhus vaccines in the parameters under study.
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