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  • Title: The gradient of basic fibroblast growth factor concentration in human pancreatic cancer cell invasion.
    Author: Hasegawa Y, Takada M, Yamamoto M, Saitoh Y.
    Journal: Biochem Biophys Res Commun; 1994 May 16; 200(3):1435-9. PubMed ID: 8185597.
    Abstract:
    It has been reported that basic fibroblast growth factor (b-FGF) is overexpressed in human pancreatic cancer cells, and that the overexpressed b-FGF contributes to the disease progression (Yamanaka et al. Cancer Res. 53, 5292-5297, 1993). Pancreatic cancer aggressively invades surrounding tissues by penetrating basement barriers. Thus, effect of b-FGF on pancreatic cancer, cell invasion to Matrigel basement membrane, was studied. The high gradient of b-FGF increased the invasiveness of human pancreatic cancer cells in a dose-dependent manner. Furthermore, the invasiveness of the cells was suppressed by anti-FGF receptor antibody. These results suggest that b-FGF plays an important role in human pancreatic cancer cell invasion to basement membrane.
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