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  • Title: Calcium efflux from cultured bovine adrenal chromaffin cells induced by bradykinin.
    Author: Houchi H, Masuda Y, Ishimura Y, Ohuchi T, Murakumo Y, Oka M.
    Journal: Biochem Pharmacol; 1994 Apr 20; 47(8):1309-13. PubMed ID: 8185639.
    Abstract:
    The effect of bradykinin on Ca2+ efflux from cultured bovine adrenal chromaffin cells was examined. Bradykinin enhanced the efflux of 45Ca2+ from the cells in a concentration dependent manner (10(-9)-10(-6) M). This effect was inhibited by a specific bradykinin B2-receptor antagonist, but not by a B1-receptor antagonist. Nifedipine, Co2+ and Cd2+ did not inhibit the bradykinin-stimulated 45Ca2+ efflux from the cells. 12-O-Tetradecanoyl phorbol 13-acetate, an activator of protein kinase C, also had no effect on the efflux of 45Ca2+ from the cells. The increase in bradykinin-stimulated 45Ca2+ efflux was reduced by removal of extracellular Na+. These results suggest that bradykinin stimulates Na+/Ca2+ exchange in cultured bovine adrenal chromaffin cells.
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