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  • Title: The effects of prostaglandin E2 injected into the paraventricular nucleus of the hypothalamus on brown adipose tissue thermogenesis in spontaneously hypertensive rats.
    Author: Bhatnagar S, Meaney MJ, Amir S.
    Journal: Brain Res; 1993 Jun 11; 613(2):285-7. PubMed ID: 8186977.
    Abstract:
    We examined brown adipose tissue (BAT) thermogenic responses to prostaglandin E2 (PGE2) injected into the paraventricular nucleus of the hypothalamus in the spontaneously hypertensive rat (SHR). 250 ng of PGE2 produced smaller increases in BAT and core temperatures in SHRs compared to their normotensive controls, the WKYs. The results of the present study suggest that the ability of SHRs to mount a febrile response may be compromised.
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