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  • Title: Gender-related differences of mouse liver D-aspartate oxidase in the activity and response to administration of D-aspartate and peroxisome proliferators.
    Author: Nagasaki H.
    Journal: Int J Biochem; 1994 Mar; 26(3):415-23. PubMed ID: 8187937.
    Abstract:
    1. The hepatic D-aspartate oxidase activity was found to be higher in female ddY and ICR mice than in their male counterparts. On the contrary, the free D-aspartate content in the liver was lower in female mice than in male mice, suggesting that D-aspartate is actually metabolized by D-aspartate oxidase in vivo. 2. Oral administration of D-aspartate to the animals increased the hepatic D-aspartate oxidase activity 2-3 fold in both genders without any significant difference in the rate of the increase between the genders. 3. Several peroxisomal enzyme activities other than D-aspartate oxidase examined were not affected by this treatment. 4. Experiments in vitro suggested that the increase in the D-aspartate activity might be explained in part by stabilization of the enzyme by D-aspartate. 5. The administration of clofibrate, a peroxisome proliferator, to male mice, increased the hepatic D-aspartate oxidase activity with a significant simultaneous decrease of D-aspartate content in the liver, in agreement with a possible role of the enzyme in vivo. 6. On the other hand, the administration of clofibrate or dehydroepiandrosterone to female mice decreased the D-aspartate oxidase activity. 7. The peroxisome proliferators were suggested to act to eliminate the gender difference of hepatic D-aspartate oxidase activity in mice.
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