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  • Title: A partial connectin cDNA encoding a novel type of RSP motifs isolated from chicken embryonic skeletal muscle.
    Author: Maruyama K, Endo T, Kume H, Kawamura Y, Kanzawa N, Kimura S, Kawashima S, Maruyama K.
    Journal: J Biochem; 1994 Jan; 115(1):147-9. PubMed ID: 8188622.
    Abstract:
    A partial cDNA encoding 811 amino acids of connectin (titin), a giant elastic protein of muscle (3,000 kDa), was cloned from a chicken embryonic skeletal muscle cDNA library using antibodies to muscle connectin. The encoded product was the C terminal segment of connectin. The predicted sequences consisted of 5 type II motifs (immunoglobulin C2 type) separated by 5 interdomain insertions. One interdomain insertion had significant homology (RSP) to KSP repeats found in human cardiac C-terminal connectin and another had a high sequence homology to porin (67.7%; 31 amino acids).
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