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  • Title: [Effect of puromycin, nalidixic acid and cycloheximide on neuromuscular transmission].
    Author: Raul F, Nesralla-Lobão H, Nery da Matta AH, Chagas C.
    Journal: C R Acad Hebd Seances Acad Sci D; 1975 Oct 27; 281(17):1247-51. PubMed ID: 819142.
    Abstract:
    The action of puromycin, nalidixic acid and cycloheximid on neuromuscular transmission has been assayed using diaphragm-phrenic nerve preparation from rat. The results demonstrate that all antibiotics used, reversibly blodk neuromuscular transmission. Cycloheximid seems to act presynaptically by inhibiting acetylcholine release from nerve terminal. Puromycin and nalidixic acid act as curare-like agents. They seem to compete with acetylcholine for fixation at the cholinergic receptor.
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