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  • Title: Identification of TEM-26 beta-lactamase responsible for a major outbreak of ceftazidime-resistant Klebsiella pneumoniae.
    Author: Urban C, Meyer KS, Mariano N, Rahal JJ, Flamm R, Rasmussen BA, Bush K.
    Journal: Antimicrob Agents Chemother; 1994 Feb; 38(2):392-5. PubMed ID: 8192474.
    Abstract:
    An epidemic of nosocomial ceftazidime-resistant Klebsiella pneumoniae was correlated with production of a ceftazidime-hydrolyzing enzyme with an isoelectric point of 5.6 (BMH-1). BMH-1 was encoded on a large transferable plasmid conferring multiple antibiotic resistance. The gene that encodes BMH-1 was identical to the gene that encodes the TEM-26 extended-spectrum beta-lactamase.
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