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  • Title: Ultraviolet-B irradiation deforms the configuration of elastic fibers during the induction of actinic elastosis in rats.
    Author: Imayama S, Nakamura K, Takeuchi M, Hori Y, Takema Y, Sakaino Y, Imokawa G.
    Journal: J Dermatol Sci; 1994 Feb; 7(1):32-8. PubMed ID: 8193082.
    Abstract:
    We used scanning electron microscopy combined with perfusion fixation, resin injection and a selective digestion procedure to determine the effects of ultraviolet-B (UVB) radiation on the three-dimensional architecture of elastic fibers of rat skin. Chronic irradiation with a suberythematous dose of UVB (3 times/week for 12 weeks) produced a tortuous deformation of the superficial elastic fibers in the skin of the rat sole which normally are linearly arranged. Using computer analysis, we evaluated 40 individuals elastic fibers every 3 weeks for 12 weeks following the irradiation. This procedure confirmed the increasing tortuosity of the fibers, which was related to a decline in the elastic property of the skin in situ. Fine elastic branches developed among the deformed fibers and eventually anastomosed to produce an irregular network in the superficial dermal connective tissue, which may correspond to the development of actinic elastosis, that is, the UV-related accumulation of elastic fiber material.
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