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  • Title: Modification of catalytic properties of chicken liver fructose 1,6-bisphosphatase by allicin.
    Author: Han J, Lawson L, Chu TC, Potter D, Han G, Han P.
    Journal: Biochem Mol Biol Int; 1993 Dec; 31(6):1007-15. PubMed ID: 8193584.
    Abstract:
    The activity of chicken liver fructose 1,6-bisphosphatase increases dramatically after incubation with allicin, a major biologically active compound produced by garlic. Activation is more pronounced when the enzyme is assayed with Mn2+ than Mg2+. Maximum activation is accompanied by the disappearance of 4 highly reactive sulfhydryl groups per molecule of enzyme. This modification also leads to loss of activation by K+, and reduced sensitivity to inhibition by AMP, fructose 2,6-bisphosphate, and high concentration of fructose 1,6-bisphosphate. All the altered properties induced by allicin can be reversed by dithiothreitol or tris(2-carboxyethyl)phosphine, the latter being much more effective.
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