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  • Title: Effect of thyroxine on DNA methyltransferase activity in cerebellum of rat.
    Author: Reddy PM, Reddy PR.
    Journal: Biochem Mol Biol Int; 1993 Dec; 31(6):1135-40. PubMed ID: 8193597.
    Abstract:
    DNA methyltransferase activity increased significantly in cerebellum from day 4 to day 8 and decreased in 30 day old rats. It was maintained at lower levels in the adult rats. Thyroxine administration markedly stimulated DNA methyl- transferase activity in the newly born pups. However, it did not cause any effect on this enzyme activity in 8 day old rat cerebellum. These results show that thyroxine has a role in the regulation of DNA methyltransferase activity in cerebellum of rat during early stages of development.
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