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  • Title: Inositol 1,4,5-trisphosphate receptor subtypes in adrenal glomerulosa cells.
    Author: Enyedi P, Szabadkai G, Horváth A, Szilágyi L, Gráf L, Spät A.
    Journal: Endocrinology; 1994 Jun; 134(6):2354-9. PubMed ID: 8194461.
    Abstract:
    Expression of the diverse subtypes of inositol 1,4,5-trisphosphate (InsP3) receptor (IP3R) was examined in rat adrenal glomerulosa cells. The polymerase chain reaction products were characterized by means of DNA sequencing and/or restriction enzyme mapping. The predominant subtype expressed is IP3R-1; its alternatively spliced variants containing and lacking segment S1 are present in comparable amounts. The expression level of IP3R-2 is about a quarter that of IP3R-1, whereas IP3R-3 is expressed at a very low level. Sodium depletion, a chronic physiological stimulus of glomerulosa cells, failed to influence the expression of IP3R-1, as measured by competitive polymerase chain reaction, and failed to modify the ratio of the different receptor subtypes, as studied with restriction enzyme mapping.
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