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  • Title: A multicenter comparative study of brodimoprim and amoxicillin therapy in the treatment of tonsillopharyngitis in adults.
    Author: Nyffenegger R, Riebenfeld D, Bandau KH, Nouri ME, Schirmböck U, Streppel M.
    Journal: J Chemother; 1993 Dec; 5(6):512-6. PubMed ID: 8195847.
    Abstract:
    STUDY OBJECTIVE: To compare the efficacy and safety of brodimoprim (BDP) with those of amoxicillin (AMX) in patients with acute bacterial pharyngitis/tonsillitis. DESIGN: Randomized controlled study. SETTING: Hospital and general practices in Austria, Germany and Switzerland. PATIENTS: 519 adult patients of both sexes aged 12 to 75 years. INTERVENTION: Patients were allocated to an 8- to 12-day treatment with BDP (400 mg loading dose followed by 200mg once a day) or AMX (750mg t.i.d). MAIN OUTCOME MEASURES: Resolution of clinical signs/symptoms and negative bacterial examination at completion of therapy. RESULTS: Clinical cure/improvement rate of 97.8% and 94.8% in respectively the BDP and the AMX group. Bacterial eradication in 87.7% of the cases treated with BDP and 88.3% of those receiving AMX. Very good/good tolerability in 85.2% BDP- and 82.8% AMX treated patients.
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