These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Domain structure and signal transduction mechanisms in the thyrotropin receptor].
    Author: Nagayama Y.
    Journal: Nihon Rinsho; 1994 Apr; 52(4):979-83. PubMed ID: 8196190.
    Abstract:
    The thyrotropin receptor is a single polypeptide (744 amino acids) consisting of two domains (N-terminal extracellular domain and C-terminal transmembrane/cytoplasmic region). The former (398 aa) contains six potential glycosylation sites, 11 cysteins and 9 leucine rich repeats and is very likely to be the major TSH binding site. On the other hand, the latter (346 aa) has a characteristic of G protein coupled receptors (seven transmembrane segments, 3 extracellular-and cyto-plasmic loops and a carboxyl terminal tail), contains potential phosphorylation sites (serine/threonine residues) for c-kinase and G-protein coupled receptor kinase and plays important roles in signal transduction and homologous desensitization. Experimentally-produced and naturally-occurring mutant receptors provide molecular mechanisms of receptor function.
    [Abstract] [Full Text] [Related] [New Search]